Compound MW (<500) LogP (<5) HBD (<5) HBA (<10) MR (40-130) Number of criteria met (At least 3) Freely rotatable bonds PSA MV
3a 408.4 3.2 1 8 110.0 All 6 118.1 286.1
3b 393.4 3.3 1 6 110.1 All 6 81.6 302.5
3c 397.8 5.7 1 5 108.9 All 5 72.3 290.2
4a 422.4 3.2 1 8 114.4 All 6 118.1 301.3
4b 407.4 3.3 1 6 114.5 All 6 81.6 317.7
4c 411.9 4.1 1 5 113.3 All 5 72.3 305.3
5a 453.4 3.8 1 11 115.6 4 7 164.0 291.4
5b 438.4 3.9 1 9 115.8 All 7 127.4 307.8
5c 442.8 4.7 1 8 114.6 All 6 118.1 295.4
Indomethacin 357.7 4.3 1 5 94.59 All 4 68.5 269.5
Table 5: Drug-likeness properties of benzimidazole derivatives.