Independent variables Levels
-2 -1 0 1 2
Extraction temperature X1 (°C) 50 60 70 80 90
Extraction time X2 (s) 360 540 720 900 1080
pH value X3 5.00 6.00 7.00 8.00 9.00
Ratio of water to raw material X4 (v/w) 20:1 30:1 40:1 50:1 60:1
Table 1: Independent variables and their levels used for central composite design.