| parameters |
Blood |
Lung |
| tl/2(h) |
2 ± 1.54 |
2 ± 1.79 |
| Cmax(mg.h/L) |
10.61 ± 2.42 |
1.53 ± 1.71 |
| tmax(h) |
1 ± 0.69 |
1 ± 0.58 |
| AUC0-inf(h·mg-1·L-1) |
33.53 ± 6.51 |
4.492 ± 2.08 |
| AUC0-t(h·mg-1·L-1） |
33.31 ± 6.37 |
4.27 ± 2.02 |
| MRT(h) |
3.45 ± 0.66 |
3.83 ± 0.74 |
Note: Cmax and tmax was the peak concentration of drug in the tissue and the time reach peak concentration. AUC0-inf and AUC0-t represented the total area under the curve and the area to the end point of observation, respectively. MRT was the average dwell time of the drug molecules in vivo. |
