| Name |
Mode of Action |
References |
| Bleomycin |
Inhibits DNA synthesis; causes cleavage at specific base sequences. Induces apoptosis and inhibit angiogenesis. |
[25] |
| Carboplatin |
Forms DNA adduct and induce apoptosis. |
[26] |
| Carmustine |
DNA alkylating/crosslinking agent effective against glioma and other solid tumors. |
[27] |
| Chlorambucil |
Alkylates DNA; In leukemia cells induces apoptosis by p53dependent mechanism. |
[28] |
| Cyclophosphamide (nitrogen mustard) |
Crosslinks DNA and causes strand breakage. |
[29] |
cisDiammineplatinum(II)
dichloride (Cisplatin) |
Induces apoptosis by forming cytotoxic adducts with the DNA dinucleotide d(pGpG). |
[30] |
| Melphalan |
Forms DNA intrastrand crosslinks by alkylation of 5'(GGC) sequences. |
[31] |
| Mitoxantrone |
Inhibits DNA synthesis by intercalating DNA. |
[32] |
