| Name |
Mode of Action |
References |
| (±)Amethopterin (Methotrexate) |
Blocks thymidine biosynthesis via inhibition of dihydrofolate reductase (folic acid antagonist) |
[42] |
3Amino1,2,4benzotriazine
1,4dioxide |
Hypoxia activated antineoplastic agent |
[43] |
| Aminopterin |
Mechanism same as methotrexate but more potent. |
[44] |
| Cytosine- β D-arabinofuranoside |
Selective inhibitor of DNA synthesis. |
[45] |
| 5-Fluoro5' deoxyuridine |
Inhibits proliferation of cancer cells transformed by HRas or Trk oncogenes |
[46] |
| 5-Fluorouracil |
Depletes dTTP and inhibits thymidylate synthetase; it forms nucleotides that can be incorporated into RNA and DNA and induces p53dependent apoptosis |
[47] |
| Ganciclovir |
In suicide gene therapy of solid tumors, the gene for Herpes
simplex virus thymidine kinase is delivered to tumor cells and expressed, which in turn activates ganciclovir cytotoxicity. |
[48] |
| Hydroxyurea |
Blocks the synthesis of deoxynucleotides by inactivating ribonucleoside reductase resulting into inhibition of DNA synthesis and induction cell death. |
[49] |
| Mitomycin C |
Inhibits DNA synthesis, nuclear division, and proliferation of cancer cells. |
[50] |
