| Name |
Mode of Action |
References |
| S(+)Camptothecin |
Binds irreversibly to the DNA topoisomerase I complex leading to the irreversible cleavage of DNA and the destruction of cellular topoisomerase I by the ubiquitin proteasome pathway. Induces apoptosis in many normal and tumor cell lines |
[72] |
| Curcumin |
Potent inhibitor of protein kinase C, EGFR tyrosine kinase and IκB kinase. Induces apoptosis in cancer cells. |
[73] |
| Deguelin |
Inhibitor of activated Akt. Does not affect MAPK, ERK1/2 or JNK. |
[74] |
| Etoposide |
Binds to the DNA topoisomerase II complex to enhance cleavage and inhibit religation; inhibits synthesis of the oncoprotein Mdm2 and induces apoptosis in tumor lines that over express Mdm2. |
[75] |
| Formestane |
Aromatase inhibitor |
[76] |
| Fostriecin |
Interferes with the reversible phosphorylation of proteins that are critical for progression through the cell cycle. |
[77] |
| Hispidin |
Potent inhibitor of protein kinase Cβ. |
[78] |
2Imino1imidazolidineacetic
Acid (Cyclocreatine) |
Creatine analog; decreases the rate of ATP production via
creatine kinase and reduces the proliferation of tumor cell lines characterized by high levels of creatine kinase expression. |
[79] |
| Mevinolin |
Inhibits mevalonic acid production and induces apoptosis in numerous cancer cell lines, perhaps, in part, by inhibiting the isoprenylation of Rhofamily GTPases. |
[80] |
| Trichostatin A |
Histone deacetylase inhibitor that enhances the cytotoxic efficacy of anticancer drugs that target DNA. |
[81] |
