| Name |
Mode of Action |
References |
| Colchicine |
Antimitotic agent that disrupts microtubules by binding to tubulin and preventing its polymerization; induces apoptosis in several normal and tumor cell lines. |
[113] |
| Dolastatin 15 |
Reported to interact with tubulin and induce apoptosis |
[114] |
| Nocodazole |
Antimitotic agent that binds to β tubulin and disrupts mitotic spindle function; Induces apoptosis in several normal and tumor cell lines. |
[115] |
| Paclitaxel |
Binds to β tubulin and promotes the formation of highly stable microtubules that resist depolymerization, preventing cell division. |
[116] |
| Podophyllotoxin |
Inhibits microtubule assembly. |
[117] |
| Rhizoxin |
Binds to β tubulin in most eucaryotic cells including animals, plants and fungi. It completely prevents formation of an intrachain crosslink in β tubulin by N,N'ethylenebis(iodoacetamide). |
[118] |
| Vinblastine |
Antimitotic agent. Inhibits microtubule assembly by binding tubulin and inducing self association; depolymerizes preexisting microtubules. Induces apoptosis in several tumor cell lines. |
[119] |
| Vinorelbine (Navelbine) |
Potent antimitotic, antitumor agent. Low neurotoxicity is related to its higher affinity for mitotic microtubules than for axonal microtubules. |
[119] |
