Entry COMP R X Zone of inhibition (mm) 50 µL for well 1Anti-bacterial activity 2Anti-fungal activity S.a B.s E.c P.a A.n P.r 1 7a H O 12 14 10 09 07 05 2 7b *Cl O 16 18 13 12 09 12 3 7c *Br O 18 16 15 11 14 10 4 7d *NO2 O 15 13 10 16 13 12 5 7e H NCH3 11 07 09 10 04 06 6 7f *Cl NCH3 17 12 15 18 11 13 7 7g *Br NCH3 19 16 12 14 09 08 8 7h *NO2 NCH3 17 13 11 14 12 14 Std Streptomycin 25 20 20 23 - - Std Fluconazole - - - - 18 15

1S.a - Staphylococcus aureus, B.s - Bacillus subtilis, E.c - Escherichia coli, P.a - Pseudomonas aeruginosa 2A.n - Aspergillus niger P.r - Penicillium rubrum *Indicates more activity

Table 1: Anti-bcterial and anti-fungal activity of 3-chloro-4-(1-(morpholinomethyl) / ((4- methylpiperazin-1-yl) methyl)-1H-imidazol-4-yl)-1-(4-substituted phenyl) azetidin-2-one 7(a-h).