| Parasite stage |
IC50 (μM) |
| Nifurtimox |
Compound 5 |
| Epimastigote |
17.4 ± 5.1 |
46.8 ± 3.7 |
| Trypomastigote |
10.0 ± 0.4 |
2.6 ± 0.2 |
| Amastigote |
18.6 ± 2.6 |
2.9 ± 0.1 |
The results are the means of three different experiments with a SD less than 10%
in all cases.
aIC50: concentration that produces 50% of inhibitory effect. |
