Compound Protein Synth. Inh. Cytotoxicity (IC50, nM)b
(EC50, nM)a A549 HCT116 Namalwa A375
ANS 32 38.5 57.2 92 57.5
22 100 87.5 67 77.7 44.4
(a) Protein synthesis was evaluated using a DLD-1 4Ub-Luc colon cancer cell line.
(b) Cytotoxicity measurements, after 72 hours of drug treatment, performed with 4 tumor cell lines.
Table 2: Protein synthesis inhibition and cytotoxicity of ANS and compound 22.