Test   Free-GHTHase PEG-GHTHase
Negative Control 2 h 6 h 2 h 6 h
Urea (mg/dl) 46.1 ± 8.1 43.6 ± 2.9 47.1 ± 2.68 42.5±17.2 42 ± 16.2
Creatinine (mg/dl) 0.9 ± 0.1 0.77 ± 0.2 1.05 ± 0.07 0.87± 0.06 0.9  ± 0.06
ALT (U/L) 46.1 ± 4.4 39.5 ± 4.1 35.4 ± 2.26 28.8±6.7 35.7 ±  2.4
AST (U/L) 35.5 ± 2.7 35.7 ± 3.0 33.5 ± 3.53 33.3±3.35 32.3 ± 2.7
Albumin (g/dl) 3.1 ± 0.1 2.8 ± 0.2 2.95 ± 0.07 3.1±0.17 3.1 ±  0.115
Total protein (g/dl) 7.1 ± 0.3 5.5 ± 0.2 5.85 ± 0.07 5.7±0.15 6.1 ± 0.15
ALP (U/L) 31.1 ± 5.7 206.7 ± 13 182.5 ± 9.2 173.3  17 197.6 ± 10.8
PLT (X 109/L) 435 ± 51 220.3 ± 14 190.5 ± 16 210.3± 19 186.3 ± 15.6
WBCs (X 109/L) 10.2 ± 2.3 8.6 ± 3.2 7.4 ± 0.1 6.86   0.7 5.4 ± 0.6
RBCs (X 1012/L) 4.52 ± 0.2 5.2 ± 0.1 5.2 ± 0.09 6 0.15 5.2 ± 0.4
HGB (g/dl) 10.53±0.1 10.7 ± 0.35 10.2 ± 0.2 10.6 0.25 8.4   3.2
Table 5: in vivo Biochemical and hematological Parameters of rabbits in response to free-GHTHase.