Proliferation inhibition (%) Compound c-Srckinase Inhibition IC50 (µM)a HT-29 SK-OV-3 MCF-7 a1 12.9 70 42 NAc a2 21 52 <30 NA a3 NDb <30 <30 <30 a4 ND <30 NA <30 a5 >300 52 40 35 a6 ND 44 35 <30 a7 30.5 45 <30 35 a8 ND 62 70 69 a9 ND 4 <30 NA a10 ND 66 52 <30 a11 ND 40 35 NA a12 ND 62 35 NA a13 27.5 37 <30 <30 a14 ND 33 <30 <30 a15 25.3 <30 <30 77 a16 36.1 52 47 45 a17 >300 45 <30 NA a18 ND 52 <30 NA a19 ND NA <30 <30 a20 35.2 67 62 50 a21 156.4 NA <30 <30 a22 21.2 76 68 35 a23 65.3 45 35 NA a24 63.1 60 <30 76 a25 ND 48 <30 NA a26 ND ND ND NDb a27 97.2 67 48 <30 a28 ND 42 37 <30 a29 95.1 <30 <30 <30 a30 46.5 60 60 <30 a31 ND <30 <30 <30 a32 ND 40 32 <30 a33 ND NA <30 <30 a34 39.2 50 35 40 a36 46.2 55 38 <30 a37 178.9 33 <30 <30 a38 30.3 68 76 55 a39 >300 <30 <30 <30 a40 ND <30 NA <30 a41 69.1 <30 NA <30 a42 33.7 40 30> <30 aThe concentration that inhibited enzyme activity by 50%; bNot determined; c No activity. All data are average of triplicate experiments.

Table 3: The biological activity of compounds a1-42.