Proliferation inhibition (%)
Compound c-Srckinase Inhibition IC50 (┬ÁM)a HT-29 SK-OV-3 MCF-7
b1 NDb <30 <30 NA
b2 41.4 <30 <30 NA
b3 ND 50.0 NA 60
b4 ND <30 <30 NA
b5 40.5 41.0 <30 <30
b6 ND NAc <30 NA
b7 ND <30 NA NA
b8 ND 40 <30 NA
b9 ND NA <30 <30
b10 36.5 NA <30 NA
b11 5.3 ND ND ND
b12 148.4 <30 NA <30
b13 29.9 32 <30 47.0
b14 ND <30 NA <30
b15 50.8 82.0 68 <70
b16 10.4 <30 NA <30
b17 ND NA NA <30
b18 23.9 NA <30 NA
b19 ND <30 <30 58.0
b20 211.8 <30 NA <30
b21 ND <30 NA <30
b22 ND <30 NA <30
b23 61.1 <30 NA <30
b24 27.7 <30 NA <30
b25 ND <30 <30 NA
b26 17.0 77.0 NA 48.0
b27 27.7 <30 <30 NA
aThe concentration that inhibited enzyme activity by 50%;
bNotdetermined;cNoactivity. All data are average of triplicate experiments.
Table 4: The biological activity of compounds b1-27.