Human cell line Cytotoxicity Origin Designation GI50 µM ± S.D. Biphenotypic B myelomonocytic leukaemia MV-4-11 29.2 ± 7.4* Acute myeloblastic leukaemia Kasumi-1 37.5 ± 5.0* Acute myeloid leukaemia PL-21 24.0 ± 11.4* Acute myelogenous leukaemia KG-1 26.4 ± 10.1* Histiocytic lymphoma U-937 22.7 ± 9.9* Pancreatic epithelioid carcinoma PANC-1 47.0 ± 26.9** Pancreatic adenocarcinoma PANC 10.05 83.4 ± 31.6** Pancreatic carcinoma MIA PaCa-2 1.9 ± 0.2** *GI50 values were determined by 72 h resazurin assay. **GI50 values were determined by 72 h MTT assay. Data given are the mean ± standard deviation derived from at least two replicates.

Table 2: Anti-proliferative activity of 4j in human cancer cell lines.