Evidence Convincing * Probable  ** Possible ***
Substantially increased risk   - -
Moderately increased risk First degree relatives Intakes of fat   Surgery for Benign Prostatic Enlargment (RRx8)
Slightly increase risk   Carbohydrates intake Vitamine E (400 UI/d) Obesity Milk diary Surgery for Benign Prostatic Enlargment (RRx2)
No association   Selenium
Lycopen
 
Slightly decreased risk   Zinc
Circumcision
Physical activity
Quercetin, Genistein, Resveratrol, Curcumin
Moderately decreased risk Dutasteride
Finasteride
Fruit and vegetable intake Epigallocatechin-3-Gallate Vitamine D
Substantially decreased risk - - -
• *>15 prospective study + mechanistic explanation
• **5 <study < 15+mechanistic explanation
• ***<5 study with mechanistic explanation or 5<study <15 without mechanistic explanation
Table 1: Prostate cancer and Prevention.