Protein Associated Neurodegenerative disease Benefit from Hsp70 elevation in vitro? Benefit from Hsp70 elevation in vivo? Benefit from Hsp90 inhibition in vitro? Benefit from Hsp90 inhibition in vivo?
Tau Tauopathies (AD, CBD, PSP, FTDP-17) Yes [61] Yes [61] Yes [62,90] Yes [62,90]
α-synuclein PD, DLB, MSA Yes [220] ? Yes[127,221] Yes [140]
LRRK2 PD Yes [138] ? Yes [139] ?
SOD1 ALS Yes [172-174] No [176] Yes [175] ?
TDP-43 ALS/FTD Yes [222] Yes [194] Yes [223] Yes [193]
Huntingtin HD Yes [211] No [212] Yes [83] Yes [212]
Androgen receptor SBMA Yes [106,206] Yes [210,224] Yes[207,209] Yes [207,208]
Ataxins SCA Yes [196] Yes [197,198] ? ?
Table 1: Shows Inhibition of Hsp90 and Hsp 70 which generates two distinct mechanisms both of which result in client protein degradation and enhanced cell survival.
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