Symptoms Treatment without ascorbic acid Treatment with ascorbic acid
1. Depressed Mood 2 ± 0.16 0.54 ± 0.24* 1.89 ± 0.20 1 ± 0.29*
2. Feeling of guilt 2.08 ± 0.24 0.38 ± 0.18* 2.22 ± 0.22 1 ± 0.37*
3. Suicide 1.31 ± 0.35 0.31 ± 0.17* 1.56 ± 0.38 0.67 ± 0.33
4. Insomnia-early 1.23 ± 0.17 0.46 ± 0.18* 1.33 ± 0.24 0.67 ± 0.24*
5. Insomnia middle 1 ± 0.23 0.15 ± 0.1* 0.89 ± 0.26 0.11 ± 0.11*
6. Insomnia-late 0.77 ± 0.20 0 ± 0* 0.89 ± 0.26 0.22 ± 0.15*
7. Work &Activities 2.46 ± 0.31 0.77 ± 0.32* 1.89 ± 0.35 1 ± 0.33
8.Retardation 0±0 0±0 0.22±0.22 0.11±0.11
9. Agitation 1.08 ± 0.21 0.15 ± 0.1* 1.44 ± 0.34 1 ± 0.29a
10. Anxiety-psychic 2.31 ± 0.17 0.69 ± 0.17* 2 ± 0.29 1.56 ± 0.29a
11. Anxiety-somatic 1.77 ± 0.12 0.46 ± 0.14* 1.67 ± 0.24 1.22 ± 0.22a
12. Somatic-symptom  GI 0.92 ± 0.18 0.15 ± 0.10* 0.89 ± 0.26 0.56 ± 0.24
13. Somatic-symptom 1.15 ± 0.19 0.46 ± 0.14* 1.33 ± 0.29 0.78 ± 0.28
14.Genital-symptoms 1 ± 0.23 0.31 ± 0.17* 0.89 ± 0.26 0.44 ± 0.24
15. Hypochondrias 1.23 ± 0.38 0 ± 0* 1.67 ± 0.37 0.78 ± 0.28a
16. Weight loss (B) 0.62 ± 0.24 0.62 ± .018 1.33 ± 0.29 0.33 ± 0.17*
17. Insight 0.08 ± 0.077 0 ± 0 0.22 ± 0.15 0.22 ± 0.15
   Total score 21.08 ± 1.26 5.46 ± 1.06* 22.33 ± 1.9 11.56 ± 2.4*a
*, significantly different from pretreatment at P ≤ 0.05; a, significantly different from group A at P ≤ 0.05; group A = ascorbic acid & antidepressant; group B = Placebo & antidepressant
Table 1: Hamilton depressions rating scale.