Dose
(mg/kg)

Gender

Period
τ (h)

Mesor ± SEM
(% of lethality)

Amplitude ± SD
(% of lethality)

Acrophase
±SD (min)b

P a

6.0

6.6

Male

Female

Male

Female

12
24
12
24
12
24
12
24

23 ± 4
25 ± 4
16 ± 3
15 ± 3
 33 ± 4
32 ± 4
30 ± 4
30 ± 4

6
13 ± 12
6
12 ± 10
10
17 ± 13
10
15 ± 14

1.8
18.8 ± 120
5.9
17.3 ± 120
4.2
18.0 ± 120
4.8
18.7 ± 120

NS
0.0004
NS
0.0001
NS
0.0007
NS
0.0003

a From an F test of the rejection of the null amplitude hypothesis.
bTime of maximum in fitted cosine function, in HALO.
NS: Not significant
Table 3: Parameters of ultradian and circadian lethality in 8 week old mice