Group n 1st turn 2nd turn 3rd turn 4th turn Total
Cis dose Interval
3 mg/kg × 5 d N/A 11 (7) 35.4 ± 4% 11.8 ±1.5% 2.9 ± 1.3% 1.9 ± 0.1% 18 ± 2%
0.1 mg/kg 30 min 7
(6)
18.9 ± 1% 10.9 ± 1% 3.7 ± 1% 1.1% 11.6 ± 3%
0.2 mg/kg 0 min 5
(4)
2 % 0 0 0 0
30 min 7
(6)
90.8 ± 5% 28.2 ± 4% 9.2 ± 1% 3.9 ± 1% 45.6 ± 2.4%
60 min 6
(6)
89.9 ± 6% 34.1 ± 4% 8.6 ± 1% 2.8% 48.6 ± 3%
90 min 8
(6)
98.2 ± 2% 45.5 ± 7% 17.4 ± 3% 5.3% 56.2 ± 1%
2.0 mg/kg 30 min 8
(6)
100% 100% 98.7 ± 1.2% 78.8 ± 3.6% 97.7 ± 2.8%
The percentage value was calculated as the result of lost OHCs divided by the total OHCs in the corresponding region. Furosemide was given at 200 mg/kg for all subgroups. n = sample size (survived animals). Interval is the time delay between furosemide and Cis administration.
Table 1: Percentage OHC loss by group and anatomical location in guinea pigs.