| Group |
n |
1st turn |
2nd turn |
3rd turn |
4th turn |
Total |
| Cis dose |
Interval |
| 3 mg/kg × 5 d |
N/A |
11 (7) |
35.4 ± 4% |
11.8 ±1.5% |
2.9 ± 1.3% |
1.9 ± 0.1% |
18 ± 2% |
| 0.1 mg/kg |
30 min |
7
(6) |
18.9 ± 1% |
10.9 ± 1% |
3.7 ± 1% |
1.1% |
11.6 ± 3% |
| 0.2 mg/kg |
0 min |
5
(4) |
2 % |
0 |
0 |
0 |
0 |
| 30 min |
7
(6) |
90.8 ± 5% |
28.2 ± 4% |
9.2 ± 1% |
3.9 ± 1% |
45.6 ± 2.4% |
| 60 min |
6
(6) |
89.9 ± 6% |
34.1 ± 4% |
8.6 ± 1% |
2.8% |
48.6 ± 3% |
| 90 min |
8
(6) |
98.2 ± 2% |
45.5 ± 7% |
17.4 ± 3% |
5.3% |
56.2 ± 1% |
| 2.0 mg/kg |
30 min |
8
(6) |
100% |
100% |
98.7 ± 1.2% |
78.8 ± 3.6% |
97.7 ± 2.8% |
The percentage value was calculated as the result of lost OHCs divided by the total OHCs in the corresponding region. Furosemide was given at 200 mg/kg for all
subgroups. n = sample size (survived animals). Interval is the time delay between furosemide and Cis administration. |
