Figure 3: Hematoxylin and eosin stain of atrioventricular heart valves (A) Control rat demonstrating some mild spontaneous myxomatous change at the distal end of the valve. (B) Rat dosed for 3 months with LY2157299. A chronic valvulopathy characterized by expansion of the valve leaflet with increased myxomatous matrix, inflammatory cells, and hemorrhage. (C) Control dog. (D) Valve from a dog dosed for 1 month with LY2157299. An acute valvulopathy characterized by marked expansion due to hemorrhage, edema, and inflammatory cells.