Figure 5: Ascending aorta from dogs dosed for 6 months with LY2157299 (hematoxylin and eosin). (A) Control dog. (B) Focally extensive disruption of the internal elastic laminae within the tunica media. (C and D) Marked disruption of the tunica media resulting in disorganization with loss of the laminar arrangement, increased prominence of mucopolysaccharide-rich ground substance, and cleft formation.