| Timea |
0 |
15 |
30 |
45 |
60 |
75 |
90 |
105 |
120 |
| |
b1b |
r2c |
b1 |
r2 |
b1 |
r2 |
b1 |
r2 |
b1 |
r2 |
b1 |
r2 |
b1 |
r2 |
b1 |
r2 |
b1 |
r2 |
| A |
−0.6 |
0.59 |
25.2 |
0.73 |
40.5 |
0.99 |
66.2 |
0.95 |
104 |
0.97 |
151.3 |
0.99 |
174.7 |
0.98 |
166.4 |
0.95 |
145.6 |
0.95 |
| HA |
−0.3 |
0.40 |
5.5 |
0.49 |
15.9 |
0.85 |
27.6 |
0.98 |
48.3 |
0.99 |
66.4 |
1.00 |
87.0 |
0.98 |
92.1 |
0.99 |
88.9 |
0.97 |
| B |
−0.1 |
0.01 |
18.8 |
0.72 |
35.4 |
1.00 |
59.9 |
1.00 |
101.5 |
1.00 |
139.2 |
0.99 |
148.4 |
0.99 |
139.5 |
0.96 |
118.6 |
0.95 |
| HB |
−0.2 |
0.40 |
10.8 |
0.92 |
14.9 |
0.91 |
25.0 |
0.98 |
41.4 |
0.96 |
63.4 |
0.96 |
77.4 |
0.97 |
83.3 |
0.96 |
80.4 |
0.96 |
| C |
0.0 |
0.05 |
1.2 |
0.54 |
4.1 |
0.96 |
9.0 |
0.99 |
15.5 |
0.99 |
22.9 |
0.99 |
25.4 |
0.99 |
23.4 |
0.96 |
19.0 |
0.92 |
| HC |
0.0 |
0.02 |
4.0 |
0.94 |
5.3 |
0.93 |
7.3 |
0.98 |
10.3 |
0.98 |
15.1 |
0.97 |
17.9 |
0.97 |
19.6 |
0.97 |
19.1 |
0.96 |
| D |
0.0 |
0.86 |
0.1 |
0.14 |
1.2 |
0.99 |
1.8 |
0.99 |
2.5 |
1.00 |
3.2 |
0.99 |
3.7 |
0.99 |
3.8 |
0.97 |
3.5 |
0.96 |
| HD |
0.0 |
0.00 |
0.2 |
0.67 |
0.2 |
0.48 |
0.4 |
0.89 |
0.5 |
0.90 |
0.6 |
0.94 |
0.7 |
0.91 |
0.9 |
0.91 |
1.1 |
0.94 |
aTime after administration (min). bβ1 (×10−8) is the slope of the
regression line for the estimated number of silica particles
administered and CL response with three concentrations and a
duplicate negative control. The CL response is the mean value of the
three measurements. cSquare of the correlation coefficient of the
regression line. |
