| |
Mean values at 3 time points (n=9) Lead CV5RL |
Difference compared to predose values |
| Pre-dose |
30 min |
60 min |
30 min |
60 min |
| Control |
1.51±0.33 |
1.47±0.51 |
1.62±0.37 |
-0.04 |
0.11 |
| 1 mg/kg |
1.65±0.41 |
2.48±0.57 |
2.25±0.74 |
0.84** |
0.61 |
| 3 mg/kg |
1.67±0.35 |
2.89±1.15 |
2.80±1.22 |
1.22** |
1.13** |
| Change compared to control at 1 mg/kg |
0.13 |
1.01*** |
0.63* |
|
|
| Change compared to control at 3 mg/kg |
0.16 |
1.42*** |
1.18** |
|
|
| *: p<0.05; **; p<0.01; ***: p<0.001 (data analyzed with a linear mixed model of analysis of variance with time, dose and the dose*time interaction as fixed effects and animal as a random effect). |
