Figure 2: Schematic of the main interactions of glucose fatty acid oxidation. The free fatty acid (FFA) enters the cell through FATP 1 and 6, is converted to FFA-CoA in the cytosol, then it moves to the mitochondria through CPT I and II. Inside the mitochondria, the acyl-CoA is transformed into acetyl-CoA to enter the Krebs cycle. Glucose enters the cell through the GLUT transporters and is converted to glucose-6-phosphate (glucose-6-P) in the cytosol. Glucose-6-P is converted to pyruvate and enters the mitochondria. The pyruvate is transformed into acetyl-CoA to enter the Krebs cycle. The glucose fatty acid oxidation cycle is the predominant regulator of the consumption of energetic substrates in the cell.