Target/assay Inhibition (% control)
concentration of OP
3μM 30μM
L-type Ca2+ channel (diltiazem site) 14 41
Na+ channel (site 2) 11 38
NMDA-type glutamate receptor (PCP) 14 23
AMPA-type glutamate receptor 4 17
Kainate-type glutamate receptor 0 14
Serotonin 5-HT2A receptor 4 13
Serotonin 5-HT4e receptor 0 13
"Extracted from reference [59]. Note that maximum concentration of OP tested was 30 μM. Hence these, especially Ca2+ channel, Na+ channel, and NMDA-type glutamate receptor, could be affected by oseltamivir; OP: oseltamivir phosphate;  OT: free form of unmetabolisedoselamivir"
Table 3: Activity of OP against molecular targets of high relevance for mood, cognition, and behavior in binding or functional assays.