Target/assay |
Inhibition (% control) |
concentration of OP |
3μM |
30μM |
L-type Ca2+ channel (diltiazem site) |
14 |
41 |
Na+ channel (site 2) |
11 |
38 |
NMDA-type glutamate receptor (PCP) |
14 |
23 |
AMPA-type glutamate receptor |
4 |
17 |
Kainate-type glutamate receptor |
0 |
14 |
Serotonin 5-HT2A receptor |
4 |
13 |
Serotonin 5-HT4e receptor |
0 |
13 |
"Extracted from reference [59]. Note that maximum concentration of OP tested was 30 μM. Hence these, especially Ca2+ channel, Na+ channel, and NMDA-type glutamate receptor, could be affected by oseltamivir; OP: oseltamivir phosphate; OT: free form of unmetabolisedoselamivir" |