Study groups

LDH

CPK

CK-MB

cTNT

Saline

129.6 ± 8.1 

211± 16.2

103.8±8.6

0.085± 0.04

CAV

363.7± 8.7

740.8± 19.1

282.7±9.6

0.82± 0.05

CAV+ Tropi

192.8± 12.2###

309.4± 18.4###

180.0±10.0###

0.45± 0.07###

Tropisetron obviously reduced serum concentration of LDH, CPK, CK-MB and cTNT increased following CAV- induced cardiotoxicity. Data are presented as mean ± S.E.M of 6 rats. ###p<0.001 CAV+ Tropi group compared to CAV group.
Table 2: The effect of pre-treatment with tropisetron (Tropi) on CAV combination chemotherapy- induced alterations in serum biomarkers of cardiac injury; (A) lactate dehydrogenase (LDH), (B) creatine phosphokinase (CPK), (C) creatine phosphokinase isoenzyme-MB (CK-MB) and (D) cardiac Troponin T (cTNT).