Metalaxyl (mg /kg/day)

0

20

40

80

Total number of fetuses (litters) examineda

External

284 (27)

263 (26)

266 (27)

279 (28)b

Visceral

142 (27)

132 (26)

133 (27)

140 (28)

Skeletal

142(27)

131 (26)

133 (27)

139 (28)

Skeletal malformations

 

 

 

 

Absence of sacrum

0 (0)

8 (5)*

10 (6)*

20 (15)*

Ribs/fused/wavy/absence/small

0/0/0/0

10 (5)*/5(4)*/5(3)*/6(3)*

7 (4)*/10(8)*/12(10)*/12(10)*

12(10)*/15(15)*/15(12)*/20(19)*

Shortening of long bones

0 (0)

0 (0)

6 (5)*

10 (10)*

Absence of metatarsals/metacarpals

4 (2)/1 (1)

12 (7)/5 (5)

15 (12)*/ 11 (9)*

23 (19)*/21 (20)*

Absence of phalanges

5 (3)

13 (8)*

20 (17)*

26 (15)*

Skeletal variations

 

 

 

 

Poorly ossified interparietal

0 (0)

1 (1)

5 (5)*

17 (15)*

Poorly ossified thoracic centrum

0 (0)

4 (4)*

11 (8)*

20 (16)*

Cranial retardation

0 (0)

9 (6)*

12 (10)*

18 (15)*

Complete ossification of fetuses

0 (0)

2 (2)*

3 (2)*

4 (4)*

Total number of fetuses (%) with skeletal malformation and variations

6 (4)

45 (34)*

66 (50)**

102 (73)**

Total number of litters (%) with skeletal malformations and variations

4 (15)

26 (100)**

27 (100)**

28 (100)**

Data are presented as n (%) of affected mice
aOnly live fetuses were examined
Significantly different from control at P ≤ 0.05
Significantly different from control at P ≤ 0.01
Table 5: Incidence of fetal malformations and variations in mice after exposure to metalaxyl on Gds 6–15.