Figure 2: Effect of pentosidine on cell viability and cellular senescence in NIH3T3 fibroblasts. (A) Water-soluble tetrazolium-1 assay showed that cell viability was not influenced by an increase in pentosidine concentration. (B) Pentosidine increased the cell senescence of NIH3T3 fibroblasts in a dose-dependent manner. Significantly higher senescence-associated β-galactosidase activity was observed in the 0.5 and 1.0 μmol/L pentosidine groups compared with that in the control group. *p<0.05; **p<0.01.