Change: Baseline to 1 Year Baseline SD Effect Size P Value KOOS         ADL 41.3 (25.7 to 57.0) 37.7 1.1 (0.68 to 1.51) <0.001 Pain 33.0 (19.2 to 46.9) 29.1 1.13 (0.66 to 1.61) <0.001 QOL 51.6 (41.1 to 62.1) 18.3 2.82 (2.25 to 3.39) <0.001 Sport 59.1 (47.4 to 70.8) 22.7 2.60 (2.09 to 3.12) <0.001 Symptoms 47.0 (34.0 to 60.0) 30.0 1.57 (1.13 to 2.00) <0.001 WOMAC         Pain 35.5 (18.3 (52.8) 38.9 0.91 (0.47 to 1.36) <0.001 Stiffness 41.1 (23.0 to 59.2) 35.4 1.16 (0.65 to 1.67) <0.001 Function 41.3 (25.1 to 57.5) 38.4 1.08 (0.65 to 1.50) <0.001

Table 2: Overall change from baseline to 1 year. P value represents Paired t-test. The effect size (change divided by standard deviation) is reported for the overall change from baseline to 1 year.