Figure 3: Bone-ligament bone constructs. Two brushite anchors are immobilised on the surface of a Petri dish and the fibrin gel is remodelled over time until a multicomponent tissue is formed. A) Day 3, B) day 7, C) day 21, D) day 35 of formation. E) Gross morphology of the hard/soft tissue interface at 18 weeks of formation. The interface between the brushite anchor and the collagenous soft tissue is still intact. F) Histological section of the hard (top)/soft (bottom) tissue interface after 6 weeks in culture. N.B. Section was left unstained to maintain the integrity of the cement portion.