Figure 5: Effects of XB130 down-regulation on U2OS xenograft tumor growth and lung metastasis. A: The tumor growth curves represent U2OS cells, XB130 shRNA-transfected U2OS cells and shRNA-transfected U2OS cells, respectively, as labeled. Point, mean tumor volume (calculated from 6 mice); bars, upper 95% confidence intervals. B: Quantification of the average pulmonary metastasis nodules from these mice with intravenously injected cancer cells. The number of experimental lung metastasis is significantly reduced after silencing XB130 in U2OS cells (*P< 0.01).