Strategy Result Reference
Designated pathogen free breeding Defined microorganisms absent in the donor pigs [82-86]
Selection of pigs with low expression of PERV-A and PERV-B and absence of PERV-C in the genome Prevent PERV-A/C recombination, low expression, possibly no particle release [87,88]
RNA interference: Expression of PERV-specific siRNA Low expression, possibly no particle release [89-92]
Zinc finger nucleases (ZFN) Attempt to eliminate all PERV [93]
Vaccine Prevent transmission of PERV [94-98]
Antiretroviral drugs Prevention/therapy [99,100]
Table 2: Strategies to increase microbiological safety.