Variable Cardiac Yes Defect No P value OSA Yes No 18 28 10 3 0.01 Asthma Yes No 45 1 12 1 0.3 Chest Infection Yes No 36 10 9 4 0.4 GER Yes No 23 23 3 10 0.08 Oxygen Yes No 28 18 7 6 0.6 PHT Yes No 37 9 7 6 0.05

OSA- Obstructive sleep apnea GER- Gatrso-esophageal reflux PHT- Pulmonary hypertension

Table 3: cardiac defect and disease association in patients with Down syndrome.