n m±SD (min-max) U/ml p* Positive cases Positive rate (%) p**
T 1a 69 285±116 (130-645) <0.0001 5 7.2 <0.0001
  1b 54 312±172 (131-1160)   5 9.3  
  2a 57 439±255 (139-1450)   16 28.1  
  2b 19 441±225 (214-1065)   7 36.8  
  3 22 586±395 (188-1676)   10 45.5  
  4 5 378±149 (199-604)   1 20.0  
N 0 168 343±217 (130-1676) 0.0047 24 14.3 0.006
  1 12 471±314 (164-1154)   5 41.7  
  2 36 465±261 (131-1450)   11 30.6  
  3 10 479±224 (222-901)   4 40.0  
M 0 210 359±219 (130-1676) 0.0003 36 17.1 <0.0001
  1a 6 591±459 (164-1450)   3 50.0  
  1b 10 570±269 (253-1160)   5 50.0  
Stage IA 103 280±117 (130-751) <0.0001 7 6.8 <0.0001
  IB 34 380±188 (139-913)   7 20.6  
  IIA 21 388±265 (207-1154)   5 23.8  
  IIB 12 633±461 (188-1676)   6 50.0  
  IIIA 28 411±198 (131-1209)   7 25.0  
  IIIB 12 434±217 (199-901)   4 33.3  
  IV 16 578±338 (164-1450)   8 50.0  
* p values indicate the results of ANOVA; ** p values indicate the results of a chisquare test.
Table 2: Serum KL-6 levels and positive rates in association with TNM stage in primary lung cancer.