Drug |
Indication & Dose |
Receptor binding |
Major Side effect |
α1 |
β1 |
β2 |
DA |
Dopamine |
Cardiogenic, septic shock, HF (2.0-20 μg/kg/min) |
+++ |
++++ |
++ |
+++++ |
Arrhythmias |
Adrenaline |
Cardiogenic, septic shock, cardiac arrest, anaphylaxis
Infusion 0.01-0.1 μg/kg/min
Bolus: 1 mg IV every 3-5 minutes (max: 0.2 mg/Kg),
IM: (1:1000): 0.1-0.5 mg (max 1 mg) |
+++++ |
++++ |
+++ |
N/A |
Arrhythmias, cardiac ischemia, sudden cardiac death |
Noradrenaline |
Septic shock, Cardiogenic shock (0.01-3 μg/kg/min) |
+++++ |
+++ |
++ |
N/A |
Arrhythmias, bradycardia, digital ischemia |
Dobutamine |
Low CO (HF, Cardiogenic shock, sepsis induced myocardial dysfunction)
(2.0-20 μg/kg/min) |
+ |
+++++ |
+++ |
N/A |
Tachycardia, arrhythmias, cardiac ischemia |
Isoprenaline |
Bradyarrhythmias
(2-10 μg/min) |
0 |
+++++ |
+++++ |
N/A |
Arrhythmias, cardiac ischemia |
Phenylephrine |
Hypotension (vagal or medicine mediated)
Bolus: (0.1-0.5 mg) IV every 10-15 minutes,
Infusion: 0.4-9.1 μg/kg/min |
+++++ |
0 |
0 |
N/A |
Reflex bradycardia, severe peripheral and visceral vasoconstriction, tissue necrosis with extravasation |
Vasopressin |
Septic Shock, cardiac arrest
Infusion: 0.01-0.04 U/min, Bolus: 40 U IV bolus |
V1 receptor (vascular smooth muscle)
V2 receptor (renal collecting duct) |
Arrhythmias, hypertension, cardiac ischemia, severe peripheral ischemia |