Variable Correlation w/ SCD p-value Age 0.123 0.099 Gender -0.106 0.157 Height -0.167 0.025 FEV1 -0.566 <0.001 FEV1% -0.652 <0.001 FVC -0.432 <0.001 FVC% -0.466 <0.001 FEV1/FVC -0.317 <0.001

Table 2: Spearman�s Correlations amongst never-smokers between baseline variables and presence of sickle cell disease (65 controls and 115 sickle cell disease patients).