Variable B p-value Restrictive ventilatory defect -0.689 0.049 Age -0.036 0.014 BMI 0.179 <0.001 CRP (log) -0.469 0.001 Male Gender 0.915 0.010 BMI = Body Mass Index CRP (log) = Natural Logarithm of C reactive protein measured in mg/L

Table 4: Linear regression with haemoglobin as outcome variable in 154 sickle cell disease patients.