Ocular Involvement Pulmonary Involvement Mediastinal Involvement Elevated SACE CARD 15 mutations Necrotizing Granuloma Fistula Formation Common Area Colon sarcoidosis May occur Common Common Common Rare May occur Absent Sigmoid Crohn’s disease Rare May occur Absent Absent Common Rare May occur Ileocecum

Table 2: Cardinal features of colon sarcoidosis and Crohn’s disease. SACE=Serum Angiotensin Converting Enzyme.