Compound
K
i
(NE) nM
K
i
(PR3) nM
Solubility (PBS, μM)
Plasma Protein Binding (% free)
Plasma Stability (t½ minutes)
CE-2072
0.24
24
<10
1.0
>100
AI-158
0.29
6.2
69.0
18.0
>100
Table 1:
Selected Biochemical and Physical Properties of the Serine Elastase Inhibitor (SEIs), CE-2017 and AI-158.
