Compound
Rat Hepatocyte Clearance (μl/min/million cells)
logD
7.4
Aqueous Solubility (μM)
RRCK Permeability Papp AB (x10
-6
cms
-1
)
1
<5
1.6
229
35
2
<5
1.5
209
7
3
Not tested
1.1
278
22
Table 3:
In vitro
pharmacokinetic properties of compounds 1, 2 and 3
