Compound
Rat iv TotalĀ Clearance
a,b
(ml/min/kg)
Oral Bioavailability
a,c
F%
T1/2
a,d
(hrs)
Vdss
a
(L/kg)
1
8.7
n/d
1.5
1.1
2
49
35
0.45
1.86
3
24
100
2.2
4.63
a
Values are means of 2 rats,
b
From 1mg/kg i.v. dose
c
From 10mg/kg oral dose
d
From i.v. PK studies
Table 4:
In vivo
rat pharmacokinetic properties of compounds 1, 2 and 3.