DEMOGRAPHICS and O2 Age Fraction males pk yr BMI Exac Prev Yr Oxygen Use n=29 60.7(8.3)* 0.66 49.2(28.2) * 25.4(3.5) * 0.57 (0.66) * 10/29 MEDICATION USE SABA LABA SAAC LAAC ICS Theophylline 2/29 26/29 2/29 23/29 23/29 3/29 BASELINE PHYSIOLOGY Baseline RV RV/TLC FEV1 DLco 6 MWT MRCD 224.2(66.6) * 0.61(0.12) * 33.0(8.4) * 349(119) * 349(119) * 3.0(0.6) * *Mean values presented with standard deviation in parentheses.

Table 1: Demographics and baseline medical and physiological characteristics of 29 patient cohort with biomarker data.