Figure 6: Immunohistochemical staining for NFκB and TNFα distribution in rats exposed to hypobaric hypoxia (6 h, 7620 m) or control (without hypobaric hypoxia) with and without curcumin administration (50 mg/Kg BW). It is noticed that, Hypoxia resulted into significant increase in inflammatory transcriptional factor NFkB and its effector proinflammatory cytokine molecule TNF-α in rat pulmonary tissue upon hypoxia exposure, indicating the increased pulmonary inflammation. However, prior treatment of rats with curcumin and exposed to hypoxia abolished the increased expression of NFκB and TNFα expressions in pulmonary tissues leading to a significant decrease in pulmonary inflammation in lungs. The figure is representative of at least 4-5 animals from each group. The signals were detected by DAB staining. Magnification: 40X.