| Malformation |
With drug |
Total |
OR/RR |
95% CI |
| Any malformation |
2206 |
70317 |
1.07 |
1.03-1.12 |
| Rel. severe malformation |
1544 |
45652 |
1.09 |
1.03-1.15 |
| Chromosome anomalies |
84 |
2932 |
1.01 |
0.81-1.26 |
| Neural tube defect |
24 |
734 |
1.13 |
0.75-1.70 |
| Other CNS malformation |
31 |
1131 |
0.92 |
0.64-1.32 |
| Severe eye malformation |
12 |
579 |
0.72 |
0.41-1.28 |
| Severe ear malformation |
4 |
280 |
0.45 |
0.12-1.15# |
| Cleft lip/palate |
44 |
1704 |
0.87 |
0.64-1.57 |
| Median cleft palate |
42 |
1002 |
1.45 |
1.06-1.98 |
| Cardiovascular defects |
533 |
16145 |
1.13 |
1.04-1.23 |
| Septum defects |
144 |
4380 |
1.11 |
0.94-1.31 |
| Esophageal atresia |
14 |
445 |
1.12 |
0.66-1.90 |
| Small gut atresia |
13 |
392 |
1.22 |
0.70-2.13 |
| Anal atresia |
21 |
590 |
1.21 |
0.78-1.87 |
| Pyloric stenosis |
46 |
1101 |
1.42 |
1.06-1.91 |
| Abdminal wall defect |
10 |
413 |
0.84 |
0.44-1.60 |
| Diaphragmatic hernia |
9 |
368 |
0.79 |
0.41-1.52 |
| Hyppospadias |
120 |
4552 |
0.87 |
0.73-1.05 |
| Severe renal malformation |
26 |
882 |
1.00 |
0.68-1.48 |
| Pes eqinovarus |
74 |
2127 |
1.14 |
0.90-1.43 |
| Poly/syndactyly |
106 |
3084 |
1.21 |
0.99-1.47 |
| Limb reduction defects |
29 |
838 |
1.16 |
0.80-1.68 |
| Craniostenosis |
84 |
812 |
1.02 |
0.69-1.51 |
| Rel. severe malformation except a cardiovascular defect |
1090 |
34940 |
1.07 |
1.01-1.14 |
# RR as observed/expected numbers with exact 95% CI. |
