Treatment Adjusteda mean difference from placebo
Trial/treatment n Adjusted mean (SE) Mean (SE) P value 95% CI
Study 1222.39          
Placebo 99 -0.054 (0.020)      
Olodaterol 5 µg 100 0.131 (0.020) 0.185 (0.020) <0.0001 0.145, 0.224
Olodaterol 10 µg 99 0.152 (0.020) 0.207 (0.020) <0.0001 0.167, 0.246
Tiotropium 18 µg 99 0.119 (0.020) 0.173 (0.020) <0.0001 0.133, 0.212
Study 1222.40          
Placebo 105 -0.008 (0.019)      
Olodaterol 5 µg 115 0.189 (0.019) 0.197 (0.017) <0.0001 0.163, 0.231
Olodaterol 10 µg 106 0.213 (0.019) 0.213 (0.019) <0.0001 0.186, 0.255
Tiotropium 18 µg 112 0.213 (0.019) 0.221 (0.017) <0.0001 0.187, 0.255
Table 2: FEV1 AUC0–12 responses (L) after 6 weeks.