Figure 1: Temporal changes in serum cell free DNA (cf-DNA) in severe sepsis patients. (Survivors in the Phase I trial are shown in open circles (?), and non-survivors in closed circles (?). The number of patients for whom serum cf-DNA levels are available is indicated. Serum cf-DNA values were higher in non-survivors than survivors at baseline and remained elevated for the duration of the study, reaching significance at 24h (*, p<0.05, ANOVA). Data are expressed as mean ± SE.)