Figure 1: Difference in mean creatinine clearance between the two groups adjusted for doublet drug (Gemcitabine or pemetrexed or other/vinorelbine/ docetaxel); planned cisplatin dose (60/75/80); smoking (never/ever); use of concomitant nephrotoxic drug (yes/no). Interval lines indicate the 98.75% confidence interval. Dotted line indicates the zero level (no difference).