LC+normal(n=70) LC+emphysema(n=26) LC+fibrosis(n=10) LC+CPFE(n=17)
Age, years old 72.5±1.5 78.8±2.0 73.8±2.1 73.9±1.9
Gender, female/male 31/39 3/23* 1/9 1/16*
Route of diagnosis, n(%)
Screening, incidental 46 (65.7%) 15 (57.7%) 4 (40.0%) 10 (58.8%)
Symptoms 24 (34.3%) 11 (42.3%) 6 (60.0%) 7 (41.2%)
Histology of lung cancer, n(%)
Small cell carcinoma 5 (7.1%) 3 (11.5%) 2 (20.0%) 1 (5.9%)
Squamous cell carcinoma 11 (15.7%) 10 (38.5%) 4 (40.0%) 10 (58.8%) **
Adenocarcinoma 50 (71.4%) 11 (42.3%) 4 (40.0%) 5 (29.4%) *
Large cell carcinoma 3 (4.3%) 2 (7.7%) 0 (0.0%) 0 (0.0%)
Other non-small cell carcinoma 1 (1.4%) 0 (0.0%) 0 (0.0%) 1 (5.9%)
Clinical stage of non-small cell lung cancer, n(%)
StageⅠA,B 31 (47.7%) 5 (21.7%) 1 (12.5%) 6 (37.5%)
StageⅡA,B 5 (7.7%) 5 (21.7%) 1 (12.5%) 5 (31.3%)
StageⅢA,B 7 (10.8%) 3 (13.0%) 1 (12.5%) 3 (18.8%)
StageⅣ 22 (33.8%) 10 (43.5%) 5 (62.5%) 2 (12.5%)
Advanced stage(ⅢB,Ⅳ) 27 (41.5%) 11 (47.8%) 5 (62.5%) 5 (31.3%)
Clinical stage of small cell lung cancer, n(%)
Limited disease 3 (60.0%) 2 (66.7%) 1 (50.0%) 1 (100.0%)
Extended disease 2 (40.0%) 1 (33.3%) 1 (50.0%) 0 (0.0%)
Initial treatment for lung cancer, n(%)
Surgery 40 (57.1%) 8 (30.8%) 3 (30.0%) 8 (47.1%)
Chemotherapy 15 (21.4%) 7 (26.9%) 2 (20.0%) 7 (41.2%)
Radiation 4 (5.7%) 1 (3.8%) 0 (0.0%) 0 (0.0%)
Best supportive care 14 (20.0%) 10 (38.5%) 5 (50.0%) 2 (11.8%)
Primary site of lung cancer, n(%)
Right upper lobe 21 (30.0%) 5 (19.2%) 3 (30.0%) 3 (17.6%)
Right middle lobe 3 (4.3%) 1 (3.8%) 2 (20.0%) 0 (0.0%)
Right lower lobe 25 (35.7%) 12 (46.2%) 0 (0.0%) 6 (35.3%)
Right hilum 1 (1.4%) 2 (7.7%) 0 (0.0%) 0 (0.0%)
Left upper lobe 9 (12.9%) 3 (11.5%) 3 (30.0%) 4 (23.5%)
Left lower lobe 10 (14.3%) 3 (11.5%) 2 (20.0%) 4 (23.5%)
Left hilum 1 (1.4%) 0 (0.0%) 0 (0.0%) 0 (0.0%)
Location of primary mass, n(%)
Upper lobe 30 8 6 7
Non-subpleural 21 (70.0%) 4 (50.0%) 2 (33.3%) 5 (71.4%)
Subpleural 9 (30.0%) 3 (37.5%) 3 (50.0%) 2 (28.8%)
Not-differentiated 0 (0.0%) 1 (12.5%) 1 (16.7%) 0 (0.0%)
Other sites 40 18 4 10
Non-subpleural 20 (50.0%) 7 (38.9%) 2 (50.0%) 2 (20.0%)
Subpleural 16 (40.0%) 10 (55.6%) 2 (50.0%) 8 (80.0%)
Not-differentiated 4 (10.0%) 1 (5.6%) 0 (0.0%) 0 (0.0%)
Non-emphysematous area N/A 2 (7.7%) N/A 4 (23.5%)
Emphysematous area N/A 24 (92.3%) N/A 13 (76.5%)
Non-fibrotic area N/A N/A 3 (30.0%) 4 (23.5%)
Fibrotic area N/A N/A 7 (70.0%) 13 (76.5%)
In-fibrotic area N/A N/A 0 (0.0%) 4 (30.8%)
Fibrotic junction area N/A N/A 7 (100.0%) 9 (69.2%)
Table 1: Clinical characteristics of the four groups.