Authors |
Publication Year |
N |
Types of Surgery |
Ventilation strategy |
Effects of low VT Vs High VT |
Two Lung Ventilation |
Wrigge et al. [72] |
2000 |
39 |
Visceral, orthopedic and Vascular |
5ml/kg ZEEP vs 5ml/kg 10 cmH2O PEEP vs 15 ml/kg 10 PEEP |
Similar plasma cytokine levels |
Wrigge et al. [73] |
2004 |
30 |
Visceral |
6 ml/kg 10 cmH2O PEEP vs. 12-15 ml/kg ZEEP |
Similar time course of cytokines in tracheal aspirate and plasma |
Choi et al. [74] |
2006 |
40 |
Visceral |
6 ml/kg cmH2O PEEP vs. 12 ml/kg ZEEP |
↙Thrombin anti-thrombin complex
↗Activated Protein C in BALF
↙Thrombomoduline in BALF |
Wolthuis et al. [75] |
2008 |
40 |
Visceral |
6 ml/kg 10 cmH2O PEEP vs. 12 ml/kg ZEEP |
Similar levels of TNF-α, IL-1, MIP-1 in BALF
↙IL-8 in BALF
↙Myeloperoxidase and elastase om BALF
Similar levels of IL-6 and IL-8 in plasma |
Reis-Miranda et al. [76] |
2005 |
62 |
Cardiac |
4-6 ml/kg 10 cmH2O PEEP+RM vs. 6-8 ml/kg 3 cmH2O PEEP |
↙IL-8, IL-10 in plasma |
Chaney et al. [77] |
2005 |
25 |
Cardiac |
6 ml/kg 10 cmH2O PEEP vs. 12 ml/kg ZEEP |
↗PaO2/FIO2
↙Static lung compliance |
Zupancich et al. [78] |
2005 |
40 |
Post-cardiac |
6 ml/kg 10 cmH2O PEEP vs. 10-12 ml/kg 3 cmH2O PEEP |
↙IL-6 and IL-8 in BALF and plasma |
Koner et al. [79] |
2004 |
44 |
Cardiac |
6 ml/kg 5 cmH2O PEEP vs. 10 ml/kg ZEEP vs 10 ml/kg 10 cmH2O PEEP |
Similar plasma TNF-α and IL-1
Similar PaO2/FIO2 |
Lee et al. [80] |
1990 |
103 |
General |
6 ml/kg vs. 12 ml/kg |
↙Pulmonary infection
↙Duration of mechanical ventilation |
Wrigge et al. [81] |
2005 |
44 |
Cardiac |
6 ml/kg 10 PEEP vs.12 ml/kg ZEEP |
↙TNF-α in BALF similar plasma cytokine levels |
Weingarten TN et al. [82] |
2009 |
40 |
Major open abdominal |
6 ml/kg 12 PEEP vs. 10 ml/kg ZEEP |
↗ PaO2/FIO2, ↗Compliance, ↙Raw
↙IL-8, ↙IL-6 in plasma (postop)
Similar length of hospital stay |
One- Lung Ventilation |
Wrigge et al. [81] |
2004 |
32 |
Lung resection |
6 ml/kg 10 cmH2O PEEP vs. 12-15 ml/kg ZEEP |
Similar time course of cytokines in tracheal aspirate and plasma |
S chilling et al. [83] |
2005 |
32 |
Lung resection |
5 ml/kg ZEEP vs. 10 ml/kg ZEEP |
↙TNF-α and sICAM in BALF
Similar levels of albumin, elastase, IL-8, IL-10 |
Michelet et al. [84] |
2006 |
52 |
Oesophagectomy |
5 ml/kg 5 cmH2O PEEP vs. 9 ml/kg ZEEP |
↙IL-1, IL-6, IL-8 in plasma
↗PaO2/FIO2 and ↙lung water content
↙Duration of mechanical ventilation |
Yang m et al. [85] |
2011 |
100 |
Lung resection |
6 ml/kg 5 cmH2O PEEP, FIO2 0.5+RM vs. 10 ml/kg ZEEP, FIO2 1.0 |
↙Postoperaive pulmonary dysfunction (PaO2/FIO2 < 300 mmHg, atelectasis) |
BALF, bronchoalveolar lavage fluid; RM, recruitment maneuver; IL, Interleukin; PEEP, positive end expiratory pressure; ZEEP, zero end expiratory pressure; TNF, tumor necrosis factor; IL-x; PaO2/FIO2, ratio of arterial oxygen pressure to fractional inspiratory oxygen pressure |