| |
Peak VO2, mL/kg/min |
Mean pulmonary artery pressure, mmHg |
Pulmonary vascular resistance index, Wood units•m2 |
Cardiac index, L/min/m2 |
| Change from Baseline |
n |
0 |
1 |
2 |
n |
0 |
10 |
20 |
n |
0 |
10 |
20 |
n |
0 |
1 |
2 |
| Placebo |
29 |
55.2 |
58.6 |
72.4 |
56 |
50.0 |
82.1 |
89.3 |
50 |
48.0 |
86.0 |
98.0 |
52 |
61.5 |
88.5 |
94.2 |
| All Sildenafil Doses Combined |
77 |
24.7 |
37.7 |
57.1 |
165 |
67.3 |
87.3 |
97.6 |
152 |
64.5 |
90.8 |
96.7 |
154 |
47.4 |
74.7 |
92.2 |
| Low Dose |
24 |
37.5 |
50.0 |
70.8 |
39 |
48.7 |
76.9 |
92.3 |
36 |
52.8 |
86.1 |
91.7 |
37 |
48.6 |
78.4 |
94.6 |
| Medium Dose |
26 |
19.2 |
34.6 |
50.0 |
55 |
74.5 |
85.5 |
98.2 |
49 |
65.3 |
89.8 |
98.0 |
49 |
51.0 |
75.5 |
91.8 |
| High Dose |
27 |
18.5 |
29.6 |
51.9 |
71 |
71.8 |
94.4 |
100.0 |
67 |
70.1 |
94.0 |
98.5 |
68 |
44.1 |
72.1 |
91.2 |
VO2=oxygen consumption.
Numbers represent the percentage of patients having less than or equal to the specified percentage change from baseline for each parameter. |
